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In other words, the cellular compartments have different GSH/GSSG ratios, and the life cell cycle is also associated with different thiol redox potentials, which can alter the cellular functions

doi:10.1038/cdd.2010.92 Albrecht P, Lewerenz J, Dittmer S et al (2010) Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target

Tobita H, Sato S, Yazaki T, Mishiro T, Ishimura N, Ishihara S, Kinoshita Y (2018) Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPK in the liver

Modifications in the B10 and B2630 regions of the B chain of human insulin alter affinity for the human IGF1 receptor more than for the insulin receptor