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Regulation of Cellular Signaling NAD+ is a cofactor for sirtuins, a family of proteins that regulate cellular processes like gene expression, stress response, and inflammation

[65] used a coculture format whereby neurons and glia could be separated after treatment for EMSA analysis, and they found that the NF-B induced by glutamatergic stimuli was restricted to glia (and, intriguingly, only glia that had been in the presence of neurons for 48 hours)