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EC50 refers to the concentration of an antibody or an antigen-binding portion thereof or an immunoconjugate described herein, that induces a response, either in an in vitro or an in vivo assay, which is 50% of the maximal response, i.e., halfway between the maximal response and the baseline

Glutaredoxin carries out GSH-dependent reduction in proteins of oxidized cysteine residues (Cys SOH, Cys SO2H), mediated and intermolecular disulfide bonds (-S-S-) to the redox-active thiol state (Ren et al., 2017)

Statistical Analysis All statistical analyses were conducted applying GraphPad Prism 8.0 software (GraphPad Software, USA)

Chem Asian J