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Recently it was reported that heme is a potent inducer of trained immunity in monocytes and macrophages both in vitro and in vivo (Figure 3) ( in vivo resulting that the outcome of heme pretreatment largely depends on the experimental conditions ( Complement Activation and the Thromboinflammatory Loop Originally the complement system has been considered as a simple mechanism to induce bacterial lysis

FIGURE 1 In this article, we will review how NRF2 activity is associated with neurodegenerative diseases, particularly with disease hallmarks such as oxidative stress, neuroinflammation and mitochondrial dysfunction

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