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Ethical complexities arise in trial design, particularly concerning vulnerable groups like incarcerated individuals and people living with HIV, requiring stringent safeguards and specialized protocols (Riste et al., 2021)

This usually resolves within 2 to 6 weeks once use is adjusted, the barrier is supported, and other actives are paused

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This insight comes from in vitro studies, which means studies done on cells isolated outside of the body (imagine scientists looking under a microscope at a petri dish)