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In: Messerschmidt A, Huber R, Poulos T, Widghardt K, editors

10.1515/jpem-2017-0322 56

Studies in cell lines often use calcitriol, as cell lines such as A549 cells express low levels of 1-hydroxylase (CYP27B1), the enzyme responsible for vitamin D activation, and are unable to convert cholecalciferol to its active form [14]