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This means millions of people are living with a condition that can cause everything from crippling fatigue to irreversible damage to the brain and nervous system if left untreated

A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway

55 Extreme cases of PMMA-induced granulomas have resulted in calcitriol-mediated hypercalcemia

Classical Ayurvedic Correlation with Pandu and Dhatu Kshaya While thalassemia as a modern genetic diagnosis is not named in classical texts, its clinical features can be correlated with Ayurvedic descriptions of Pandu , Rakta Kshaya , and Dhatu Kshaya , where pallor, weakness, exertional fatigue, reduced strength, and poor tissue quality are emphasized