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5.1.3 Neurotraumatic diseases 5.1.3.1 Spinal cord injury In recent years, researchers from the International Collaboration on Repair Discoveries at the University of British Columbia, Canada (130132), applied EODF to treat rats with acute incomplete cervical and thoracic spinal cord injury (SCI), obtaining positive results in behavioral assessments and evaluations of neuroprotective effects through blood -hydroxybutyrate levels and BDNF levels

Individuals with common diseases but with a low polygenic risk score could be prioritized for rare variant screening

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Instead, if lysosomal repair fails or if there are large lysosomal ruptures, LGALS3 is responsible for the switching from ESCRT response to lysophagy, recruiting proteins involved in ubiquitination of lysosomal proteins and autophagy regulators