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Several situations warrant pausing at a dose level for additional weeks before escalating: Persistent nausea: If nausea lasts beyond 2 weeks at any dose level, stay at that dose for an additional 2 to 4 weeks

Mol Neurobiol 54:36523664 Xifro X, Vidal-Sancho L, Boadas-Vaello P, Turrado C, Alberch J, Puig T, Verdu E (2015) Novel epigallocatechin-3-gallate (EGCG) derivative as a new therapeutic strategy for reducing neuropathic pain after chronic constriction nerve injury in mice