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The high proline content (4 of 15 residues, including a triple Pro-Pro-Pro stretch at positions 3 to 5) gives BPC-157 unusually good resistance to gastric and intestinal proteases, which is why some published animal work uses oral administration

The fragment used in many TB500 preparations corresponds to a 43aminoacid sequence related to the native protein

Blast-exposed mice have been reported to display phosphorylated tauopathy, myelinated axonopathy, microvasculopathy, persistent and chronic neuroinflammation in the absence of overt tissue damage and hemorrhage (Goldstein)