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In neuronal cultures and APP SWE /PS1 E9 model mice, infection induces amyloid-, inflammasome activation, neuroinflammation, and neurotoxicity, and chronic infection worsens cognition

30 A-D creatinine levels of all vehicle-treated C57BL/6 mice exceeded 2.0 mg/dL and showed strong morphologic damage and high serum urea levels whereas Fer-1-treated and, to a greater extent, SRS16-86-treated mice were protected from functional acute renal failure ( FIGS