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Growing evidence indicates that PINK1 acts as a crucial regulator of mitochondrial quality control through stabilization of cristae structure, phosphorylation of chaperone proteins, and regulation of mitophagy (Wang et al., 2011b)

mtDNA damage The most striking difference between mitochondria and other organelles is that they have a separate set of genetic materials (mtDNA) consisting of 13 protein-coding genes, 22 tRNA genes, and 2 rRNA genes, which assist in maintaining mitochondrial function

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

and, ii) a pharmaceutically acceptable nanocontainer comprising the agent, wherein the ligand in a) is conjugated to at least one of the agent and the nanocontainer in b)