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[11, 12] These ligands can specifically identify and bind to the receptors typically overexpressed on cancer cells or tumor neovascular endothelial cells in the tumor microenvironment to achieve active target accumulation

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Probucol attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in dogs

Of note, our recent findings also demonstrated that melatonin exerts antibacterial activity against GNB (e.g., Klebsiella , Pasteurella multocida and Pseudomonas aeruginosa ) through specifically inhibiting the activity of bacterial citrate synthase ( Figure 1E ), and the combination of colistin with melatonin enhances bacterial outer membrane permeability, oxidative damage and inhibits the effect of efflux pumps ( Figure 1F ) (126)