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Studies suggest that Fluoxetine can increase the expression of Claudin-5 and its effect on Wnt signaling may help restore BBB function while promoting neurogenesis [143, 144]

Nociceptive neurons are endowed with a series of receptors, such as innate immune system receptors, like Toll-like receptors (TLR), which can directly detect the presence of a pathogen and send danger signals to the immune system, for instance through the secretion of neuropeptides that activate immune cells

Addressing these areas will not only deepen the understanding of ferroptosis in LN but also facilitate the development of precise, translatable biomarkers and therapies for this severe autoimmune kidney disease