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Symptoms have occurred at MetHb levels ranging from 1.9% to 26.8%, mostly at the 100-mg dose

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The accumulation of free cholesterol in LSEC endolysosomes disrupted Rab7 membrane trafficking and impaired the transport of TLR9 from late endosomes to lysosomes, enhancing activation of the TLR9/inflammasome pathway mediating APAP-induced liver injury

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AICD: activation-induced cell death AIF: apoptosis-inducing factor BSO: L-buthionine-( S,R )-sulfoxime CD95-L: CD95 ligand CD95: CD95 receptor DISC: death-inducing signaling complex Doxo: doxorubicin m: mitochondrial membrane potential FADD: Fas-associated death domain FSC: forward scatter GSH: glutathione NGF: nerve growth factor PARP: poly(ADP-ribose)polymerase PFA: paraformaldehyde PI: propidium iodide PMSF: phenyl methyl sulfonyl fluoride PT: permeability transition ROS: reactive oxygen species SSC: side scatter TNF: tumor necrosis factor XIAP: X-linked inhibitor-of-apoptosis protein References Kaufmann SH and Earnshaw WC (2000) Induction of apoptosis by cancer therapy