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The next paragraphs will discuss genetic predisposition and susceptibility as an underlying risk factor for ME/CFS - the superimposition of external stressors and exposures (59) results in a state of aberrant homeostasis, where a temporary homeostatic state of functioning occurs, but functions at a less optimum level (64)

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The ligated cysteine makes an additional two hydrogen bonds to amino acid side chains, one to the Tyr10 OH atom, and one to the Tyr106 OH atom, and a further hydrogen bond to the main chain N atom of Arg16