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The attachment inhibitor fostemsavir is an oral prodrug that is hydrolyzed to the active form temsavir, which binds to the HIV gp120 envelope adjacent to the gp120-CD4 binding site.[16,17] The binding of temsavir prevents the gp120 conformational change required for normal attachment to the CD4 receptor.[16] Postattachment Inhibitor : The initial attachment of HIV to the CD4 cell occurs between the domain 1 region of the host CD4 receptor and the HIV gp120 binding site

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