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SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

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In liver injury, CHAC1s promotion of GSHdegradation accelerates oxidative stress and liver cell death, while in atherosclerosis, it contributes to plaque instability by promoting apoptosis in lesional macrophages and smooth muscle cells (Xu et al., 2023

These exosomes reduced tau phosphorylation through cyclin-dependent kinase 5 (CDK5) suppression, minimized neurofibrillary tangle formation, and decreased caspase-3/9 activity, emphasizing their neuroprotective potential [125]