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Gene expression profiling revealed distinct apoptotic pathways: low-dose exposure triggers apoptosis through cellular stress responses, while high-dose exposure primarily activates it via direct DNA damage (160)

doi: 10.1016/s0021-9150(00)00524-4

doi: 10.1159/000490142 123 MoonHJParkSYLeeSHKangCDKimSH

Human translation timelines are less defined due to limited clinical data, but based on pharmacokinetic principles and the upstream nature of NNMT inhibition, expect detectable metabolic shifts within 68 weeks if dosing and purity are appropriate