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3.2 Metabolic zonation of liver As the smallest structural unit in the liver, hepatic lobules can be divided into three zones based on the different metabolic functions of hepatocytes at different locations in the liver lobules: the hepatocytes adjacent to the portal vein triad constitute Zone 1, the hepatocytes adjacent to the central vein constitute Zone 3, and the hepatocytes in between constitute Zone 2 (49)

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They may argue against this, but the truth is that pasteurizing requires heating the milk to temperatures that reduce, change or destroy a significant amount of its raw nutritive value