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Experimental Biology and Medicine, 246(13), 15001511

doi: 10.1016/j.cmet.2013.01.013

Abstract Treatment with 0.2 mM hydrogen peroxide (H 2 O 2 ) or with 0.5 mM cisplatin caused caspase-9 and caspase-3 activation and death by apoptosis in U-937 human promonocytic cells

Using a combination of imaging, biochemical, lipidomic, in vitro , and ex vivo assays, we show that ORP5 stabilizes PA at ER-mitochondria subdomains and preferentially favors its transfer from mitochondria toward the associated ER for TAG synthesis