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Oral administration allows for easy daily use without the discomfort, complexity or potential side effects associated with injections

People who have had surgery to remove the stomach or the end of the small intestine may also not be able to absorb vitamin B12

[83] In August 2021, the US Centers for Disease Control and Prevention (CDC) published a study reporting that the effectiveness against infection decreased from 91% (8196%) to 66% (2684%) when the Delta variant became predominant in the US, which may be due to unmeasured and residual confounding related to a decline in vaccine effectiveness over time

Successful absorption requires the successful completion of several different steps: The stomach secretes a special molecule called intrinsic factor for the sole purpose of facilitating absorption further down the digestive tract