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Such recycling is believed to be triggered by conformational changes in PrP, which could occur in response to decreasing pH along the endocytic pathway and lead to the dissociation of Cu from PrP 29

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Nevertheless, the identification of Bmal1 and Clock in the rat lens supports another study that identified Bmal1 and Clock at the mRNA level in human lens epithelial cells and mouse lenses ( At the protein level, BMAL1, CLOCK and CRY2 were detected in the lens, but CRY1 and PER1-3 was undetectable ( Figure 2 ), suggesting that these proteins may be more abundantly expressed during the night compared to during the day

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