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Science 232 , 16291632

4.2 Other amino acid Research has illuminated that the tryptophan metabolite, 5-hydroxytryptophan (5(OH)Trp), holds promise in mitigating symptoms of mouse models with psoriasis-like dermatitis

In the book Tipping Point, the concept of tipping points is related to small initial changes leading to a runaway process, that ultimately cause big transitions (Gladwell, 2001)