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Connors J, Dawe N, Van Limbergen J (2019) The role of succinate in the regulation of intestinal inflammation

The extrinsic pathway is triggered by ligand binding (e.g., FAS, TNF-, TRAIL) to their receptors, activating FADD, which in turn activates caspase-8 and caspase-10, ultimately leading to apoptosis via caspase-3 and caspase-7 [33]