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Endotoxins are amphiphilic molecules with a hydrophilic polysaccharide chain and a lipophilic lipid A tail that in the presence of bile acids in the intestinal lumen can form micellar aggregates

Although it is generally assumed that microglia secrete the majority of effector molecules, our data show that in the initial disease phase of the cuprizone model microglia do not themselves contribute to the upregulation of IL6, IL1, TNF or CCL2