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doi: 10.1111/j.1743-6109.2009.01499.x 109 SelphJPCarsonCR

2) RANKL/OPG balance: most innate immune mediators (e.g., M1 macrophages, NETs, C5a) disrupt this balance by upregulating RANKL or downregulating OPG, enhancing bone resorption

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