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2023, 15.: 10.3390/nu15020352 Abebe W: Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues

Indeed, a vicious circle hypothesis has been proposed [26] , suggesting that an initial defect in ISC biogenesis leads to mitochondrial iron overload, which subsequently generates excessive ROS that oxidatively damage the few remaining intact ISCs, further exacerbating the pathology