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A subset of dedifferentiated -cells were at early stage to convert into -cell in LOsG-treated animals As a subset of FoxO1-deficient -cells adapts the -cell fate, resulting in hyperglucagonemia 22 , we determined pancreatic glucagon mRNA in LOsG-treated -cells, which were associated with low or absent FoxO1 expression

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Other reported adverse events include neuropsychiatric disorders such as dopaminergic dysregulation syndrome, dopamimetic-induced psychosis, and impulse control disorder [14, 27]

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