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In a study on breast cancer, ALA-treated MDA-MB-231 and 4T1 breast cancer cell lines both exhibited downregulated expression of EMT markers such as Snail, vimentin, and Zeb1, along with impaired cell migration capabilities [73]

Thus the discovery of cuproptosis reveals that the targets and pathways involved in Cu-dependent cell death are highly correlated with mitochondrial respiration proteins, showing increasing expect for drug discovery

However, athletes involved in moderate and high-volume training need greater amounts of carbohydrate and protein (discussed later) in their diet to meet macronutrient needs [50]