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This is because the retina, including the RPE, like most neural ectoderm-derived tissues, is highly oxygen-sensitive and critically dependent on a stable oxygen supply for its metabolism and function

By restoring and maintaining proper pH balance, protecting bone density, supporting muscle function, and modulating insulin metabolism, RMF creates the internal conditions that allow both glutathione production and immune cell activity to operate at full capacity over the long term

Lactate accumulation, resulting from the glycolytic shift, creates a metabolic microenvironment conducive to ferroptosis [133]

Alternatively, the expression levels of certain components of these signaling pathways might be useful to predict the efficacy of targeted degradation therapies