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(212), The GM is crucial in regulating both innate and acquired immunity, while simultaneously generating immune intermediates that are indispensable for the development of pro- and anti-inflammatory responses. Figure 4 7.1 Modulation of T cell responses and differentiation The GM is intricately associated with the equilibrium between T helper 17 (Th17) cells and Tregs, suggesting that intestinal bacteria may provoke a disruption in Th17/Treg immunity (213)