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These SPIONs, such as mannose-coated SPIONs, have been extensively explored in pain models for their CAT- and POD-like activities, and their ability to modulate oxidative stress may contribute to therapeutic effects beyond hyperthermia [132]

One such key protein is ZnT8, which is essential for the crystallization, processing, storage, and secretion of insulin, as well as the overall metabolism of glucose [67]

AngII has been shown to activate AT1Rs, inducing mitochondrial dysfunction and oxidative stress in hepatocytes through the downregulation of antioxidant enzymes (SOD2 and GPx1) and elevated pro-inflammatory mediators (TNF-, monocyte chemoattractant protein 1 and IL-8) (21), and these effects may negatively impact cell membrane sodium/water retention and the development of pathological changes such as cytoplasmic vacuolization and hepatocyte edema

Cordycepin and kinase inhibition in cancer