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In recent studies using BRET (Bioluminescence Resonance Energy Transfert) or FRET (Fluorescence Resonance Energy Transfer) techniques, a large panel of opioid ligands were shown to have a different ability to both activate G proteins and recruit arrestins at MOR and DOR (Mcpherson et al., 2010

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In animal models of inflammation, DSF treatment resulted in reduced levels of TNF- and IL-6, demonstrating that DSF effectively suppresses NF-B-driven inflammatory responses (Huang et al., 2022