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To understand why this happens, we have to go to the synaptic cleft, or the connection between neurons

However, 44% of patients only respond to PN, probably due to residual enzyme activity that converts PN to PLP [37]

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis