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Through inducing ROS production and activating JNK pathway, ISA can increase the antitumor effects of doxorubicin in colon cancers (thus lowering the cardiotoxicity of doxorubicin) (Wu F

E., McDonnell, M

however, the drugs undergo extensive first-pass metabolism in the liver, with only about 50-60% of a dose of diclofenac sodium or diclofenac potassium reaching systemic circulation as unchanged drug

The identification of two isoforms generated from the alternative splicing (IR-A) of the full-length transcript (IR-B) results in a 12-amino difference between the two isoforms [35] and differential expression during mammalian development