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10.1016/j.jhep.2018.03.011 212 TurpinS

Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

However, numerous research indicate that immune system has a dual role in APAP-overdose challenge [36, 37, 39, 42, 43], which may be related to the specific roles of the immune cells in exacerbating liver damage or promoting liver repair and regeneration (Fig

-Age-This factors is rarely considered in discussion of BAC, but it is important