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(2011) demonstrated that NF1 heterozygosity resulted in increase in microglia specifically within optic nerve, and not in brainstem or neocortex

As discussed elsewhere, the role of IFN-I in tumor biology and immune responses is, per se, dichotomous, promoting cytotoxicity of NK cells and CD8 + T cells in some circumstances but also the suppressive function of Tregs in others [177,178,179]