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Its combined appetite-suppressant and energy-expenditure effects make it more effective than traditional GLP-1 monotherapies, offering a potential breakthrough in obesity treatment

Although effective in vitro, it displayed weak activity in vivo and could not be widely applied

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As neurosteroids, DHEA and DHEAS can bind directly to neurotransmitter receptors, and have been found to modulate neural activity by acting as noncompetitive antagonists at GABAA receptors, reducing inhibitory neurotransmission, and as positive allosteric modulators at NMDA receptors, enhancing excitatory signaling, and facilitating dendritic growth, axonal elongation, and synaptic plasticity in response to environmental stimuli (, )