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The living beings evolved passing from the anaerobic to the aerobic conditions, what happened thanks to the efficient antioxidant system development, where the enzymes superoxide dismutase, glutathione peroxidase and catalase play a fundamental role to the species preservation and perpetuation whose metabolism is aerobic (Halliwell and Gutteridge, 1985)

In 1978 they reported the isolation, amino-acid sequence, and synthesis of the nonapeptide, naming it Delta Sleep-Inducing Peptide

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