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10.1016/j.biomaterials.2017.01.017 26 EbrahimianM.TaghaviS.GhoreishiM.SedghiS.AmelF

Two of these are balanced by two negative charges on two of the four nitrogen atoms in the planar corrin ring, which is less symmetrical than the corrin ring in ferro-hemeproteins

The lyophilization processbasically, sophisticated freeze-dryingremoves the water, which dramatically slows down these chemical reactions, putting the molecule into a state of suspended animation