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Glutamine-derived -KG can enter the TCA cycle to produce energy for the cell or proceed backwards via the reductive carboxylation to provide an alternative source of lipid synthesis

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When recruited, it becomes oligomerized and is transported to mitochondria where it interacts with protein adaptors, such as the mitochondrial fission factor (Mff), the mitochondrial fission protein 1 (Fis1), the mitochondrial dynamics protein 49 (MiD49/MIEF2), and the mitochondrial dynamics protein 51 (MiD51/MIEF1) [315]