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[DOI] [PMC free article] [PubMed] [Google Scholar] 245.Gibson AA, Seimon RV, Lee CM, et al

Immunohistochemical biomarkers, including S-100 (90% positivity), HMB-45 (95.5% positivity), and Melan-A (100% positivity), play a fundamental role in confirming the diagnosis

A tryptophan at position 741 would result in a steric clash that would block H12 from adopting its agonist conformation (Figure 5C)

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