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The direct use of humans as experimental subjects is very dangerous and can lead to unknown consequences

Interferon epsilon loss is elusive 9p21 link to immune-cold tumors, resistant to immune checkpoint therapy, and endogenous CXCL9/10 induction

High GSH content within astrocytes protects them from oxidative stress and preserves their ability for glutamate uptake, ion homeostasis, and immune signaling (Takahashi and Mashima, 2022)

This highlights an important conceptual point: ferroptosis sensitivity is determined not only by GSH abundance but also by the metabolic capacity to sustain reductive flux under oxidative stress