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Numerous previous studies have demonstrated that MetS augments an individual's susceptibility to developing chronic kidney disease (CKD) (3)

LA induces gene expression changes Then, we assessed the expression levels of well-known cell cycle regulators as the member of the AP1 transcription factor complex namely c-fos, the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21 Cip1/WAF1

An independent study stained 173 cutaneous sebaceous lesions for Lynch syndrome proteins (via IHC) in patients who were not known to have a Lynch syndrome diagnosis.[19] Fifty-three percent (92/173) of these cutaneous sebaceous lesions had abnormal IHC results

However, preclinical models always constitute approximations and simplifications, and therefore, results should be interpreted with caution (180)