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The effect on bioactive components and characteristics of chocolate by functionalization with raw cocoa beans

Glioma clumps formed by GBM lead to the upregulation of Piezo1 expression, which, in turn, promotes the rapid proliferation and invasion of glioma cells, accelerates the spreading range and speed of the clumps, and creates a vicious cycle (Velasco-Estevez et al., 2020), and changes in mechanical forces may lead to the activation of Piezo1 channels, exacerbating ischemic brain injury (Zhou et al., 2020)