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Microbiome 17 , 33 (2022)

Activated JAK2 phosphorylates specific tyrosine residues on the growth hormone receptor, creating docking sites for Signal Transducer and Activator of Transcription 5B (STAT5B) proteins

In high-altitude cerebral edema (HACE) which is characterized by inflammation and hypoxia, proteins in the nucleosome remodeling and histone deacetylase (NuRD) complex of microglial is lactylated, which upregulates the expression of various pro-inflammatory factors in M1-type microglia and enhances NF-B pathway activity, thereby exacerbating LPS-induced neuroinflammatory conditions [133]

Curcumin prevents chronic alcohol-induced liver disease involving decreasing ROS generation and enhancing antioxidative capacity