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On the other hand, accumulation of misfolded proteins per se was shown to directly inhibit the proteasome activity [78], exacerbating these toxic effects

DBS targeting the ventral medial prefrontal cortex is thought to exert its antidepressant-like and cognitive enhancement effect by increasing expression of BDNF, Akt, and mammalian target of rapamycin (mTOR), and observed to restore stress-induced synaptic loss in the hippocampus (131)

P.SafarA.SchutzlerS.MemelinkR.FerrandoA.SpencerH.et al (2011a)

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