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This inflammatory milieu perpetuates a cascade of responses from T cells, osteoclasts, and chondrocytes [63]

Similarly, intranasal delivery of the closely related commensal Neisseria lactamica prevented meningococcal meningitis in mice (Li et al., 2006) and nasal delivery of a commensal Pasteurellaceae species was able to delay onset of OM in mice (Granland et al., 2020)