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Moreover, administration of 7-KC in Tohoku Hospital Pediatrics-1 (THP-1) cells - a human monocytic leukemia cell line derived from a patient with acute monocytic leukemiainduced ERK-1/2 phosphorylation increasing apoptosis significantly (Berthier et al., 2005)

Meanwhile, suppression of glycogen phosphorylase induces apoptosis in ATC cells, which means glycogen metabolism provides new targets for TC treatment [278]

The Grx1-roGFP2 fusion protein, which combines human glutaredoxin with roGFP2, further enhances sensitivity and dynamic range, making it particularly effective for monitoring rapid and subtle changes in glutathione redox potential across different cellular compartments

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1